Infections caused by microorganisms sensitive to the drug: respiratory tract infections including pneumonia, bronchitis; infections of skin and subcutaneous tissue; intra-abdominal infections, including peritonitis and biliary tract infections; gynecological infections; septicemia. Empiric therapy for febrile neutropenic patients. Prevention of postoperative complications in intra-abdominal surgery. Pneumonia; urinary tract infections, including pyelonephritis; infections of skin and subcutaneous tissue; septicemia; empiric therapy for febrile neutropenic patients; bacterial meningitis.

As a single agent or as a part of combined therapy of dental diseases (stomatitis, gingivitis, glossitis, periodontitis), upper respiratory tract diseases (pharyngitis, tonsillitis, including post-tonsillectomy condition, laryngitis, and pharyngo- and laryngotracheitis, chronic bronchitis); in gastroenterology (gastric and duodenal ulcers, acute and chronic gastritis, duodenitis, colitis and enterocolitis of various origin), in proctology (proctitis, proctosigmoiditis, hemorrhoids, skin itching in the anal and perianal areas), in gynecology (cervical erosion, colpitis, cervicitis, laceration of the perineum and vagina occurring during delivery).

Adding to standard treatment with the use of beta-blocker with the purpose of decline of risk of the morbidity and death rate, related to the cardiovascular diseases, for stable patients with disfunction of the left ventricle (faction of the troop landing of the left ventricle ≤40%) and the clinical signs of heart failure after the recently carried heart attack of myocardium.
Adding to standard optimal therapy with the purpose of decline of risk of morbidity and death rate related to the cardiovascular diseases, for adult patients with the heart failure of II of class (chronic) on classification of NYHA and disfunction of the left ventricle (faction of the troop landing of the left ventricle ≤30%).

Acute and chronic infections of respiratory tract and nasopharynx (bronchitis, sinusitis, tonsillar angina, rhinopharyngitis).

Pathogenetic therapy of inflammation and pain in osteoarthritis and rheumatoid arthritis.

Comprehensive treatment of coronary heart disease (post-myocardial infarction, angina), chronic cardiac arrhythmias, cardiac glycosides intoxication medicinal products, treatment of cardiomyopathies of various origins, myocardial (compared to strenuous exercise, infectious and endocrine genesis), myocarditis, liver disease (hepatitis, cirrhosis, fatty liver), urokoproporfiria. To improve the visual function at open-angle glaucoma with normalized intraocular pressure.

Combined therapy of ischemic heart disease (post-infarction state, angina), heart rhythm disorders induced by cardiac glycosides, treatment for cardiomyopathies of various genesis, myocarditis (associated with physical exertion), liver diseases (hepatitis, cirrhosis, fatty liver disease), urocoproporphyria, prophylaxis of leukopenia associated with radiation therapy. Riboxin is used in cases of open-angle glaucoma with normalized (due to antihypertensive drugs) intraocular pressure as a means for vision improvement.