Diseases associated with hypocalcemia, increased cell membrane permeability, impaired transmission of nerve impulses in muscles. Hypoparathyroidism (latent tetany, osteoporosis), disturbances in vitamin D metabolism (rickets, spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure. High calcium requirements (the period of intensive growth in children and adolescents, pregnancy, lactation), nutritional Ca2+ deficiency, disorders of calcium metabolism in postmenopausal period, bone fractures. Intensive loss of Ca2 + (long-term bedridden patients, chronic diarrhea, hypocalcemia, long-term administration of diuretics, antiepileptic drugs, corticosteroids). As a part of combined therapy of bleedings of varying genesis, allergic diseases (serum sickness, rash, fever syndrome, pruritus, itching dermatoses, angioneurotic edema); bronchial asthma, hunger edema, pulmonary tuberculosis, eclampsia, parenchymatous hepatitis, toxic liver damage, nephritis. Poisoning with magnesium salt, oxalic acid, soluble salts of fluoric acid (binding to calcium gluconate results in forming insoluble and non-toxic calcium oxalate and calcium fluoride).