How supplied Solution for injections 2% in 5 ml ampoules №10; 10 ml ampoules №10.
1 ml of solution contains 20 mg of riboxin;
excipients: hexamethylenetetramine, 1 M solution of sodium hydroxide, water for injections.
Combined therapy of ischemic heart disease (post-infarction state, angina), heart rhythm disorders induced by cardiac glycosides, treatment for cardiomyopathies of various genesis, myocarditis (associated with physical exertion), liver diseases (hepatitis, cirrhosis, fatty liver disease), urocoproporphyria, prophylaxis of leukopenia associated with radiation therapy. Riboxin is used in cases of open-angle glaucoma with normalized (due to antihypertensive drugs) intraocular pressure as a means for vision improvement.
Individual hypersensitivity to the drug. Gout, hyperuricemia. Renal failure is a limitation to Riboxin therapy.
Dosage and administration
In adults and older children, the medication is administered by intravenous drip infusion or bolus injection. Initially 200 mg (10 ml of 2% solution) are administered once daily with further dose increase, if well tolerated, to 400 mg (20 ml of 2% solution) 1-2 times daily. The treatment course should be determined individually (10 - 15 days on average).
For intravenous drip infusion, 2% solution is diluted with 5% glucose solution or isotonic sodium chloride solution (up to 250 mg).The drug is administered slowly at a rate of 40 - 60 drops per minute.
For acute heart rhythm disorders, the drug may be administered by bolus injection in a single dose of 200 - 400 mg (10 - 20 ml of 2 % solution).
Pruritus and skin hyperemia may occur in patients hypersensitive to the drug. In isolated cases, elevated uric acid levels could be observed during riboxin treatment. Long-term administration may result in exacerbation of gout. If adverse reactions occur, the drug should be discontinued.